Hairy cell leukemia HCL

• Facts:
  Malignant disorder of well-differentiated B lymphocytes
  
  MC affects older males
• History / PE:
  Weakness
  
  Fatigue
  
  Easy brusing
  
  Splenomegaly
• Diagnosis:
  Bone marrow becomes fibrotic (dry tap)
  
  Tartrate-resistant acid phosphatase (TRAP) staining
  
  Leukopenia
  
  CD 11c marker
  
  Fine, hair-like irregular projections from lymphocytes
• Treatment:
  Nucleoside analogs (eg. cladribine)
• See Also:
  White blood cell disorders
• Associated With:
  Mycobacterium avium-intracellulare