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Hematology

Langerhans histiocytosis

Langerhans histiocytosis LCH

Langerhans histiocytosisLangerhans histiocytosis

  • History / PE:
    Solitary, painful, lytic long bone lesion

    Hypercalcemia

    Overlying, tender swelling

    Pathological fractures
  • Diagnosis:
    Birbeck granules on EM
  • Treatment:
    Typically resolves spontaneously

    Treated conservatively
  • Associated With:
    Hand–Schüller–Christian disease (children)

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