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Hematology

Hairy cell leukemia

Hairy cell leukemia HCL

Hairy cells

  • Facts:
    Malignant disorder of well-differentiated B lymphocytes

    MC affects older males
  • History / PE:
    Weakness

    Fatigue

    Easy brusing

    Splenomegaly
  • Diagnosis:
    Bone marrow becomes fibrotic (dry tap)

    Tartrate-resistant acid phosphatase (TRAP) staining

    Leukopenia

    CD 11c marker

    Fine, hair-like irregular projections from lymphocytes
  • Treatment:
    Nucleoside analogs (eg. cladribine)
  • See Also:
    White blood cell disorders
  • Associated With:
    Mycobacterium avium-intracellulare

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