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Hematology

Factor V Leiden

Factor V Leiden

  • Facts:
    MC inherited disorder causing hypercoagulability and predisposition to thrombus, especially DVT of the lower extremities

    Result of a point mutation in gene encoding for the coagulation factor V

    Factor V becomes resistant to inactivation by protein C

  • History / PE:
    Recurrent thrombotic complications

    Recurrent miscarriages (women)
  • Differential Diagnosis:
    Protein C deficiency

    Protein S deficiency

    Antithrombin III deficiency

    Hyperhomocysteinemia

    Antiphospholipid syndrome (acquired)

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