Hematology
Factor V Leiden
Factor V Leiden
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- Facts:
- MC inherited disorder causing hypercoagulability and predisposition to thrombus, especially DVT of the lower extremities
Result of a point mutation in gene encoding for the coagulation factor V
Factor V becomes resistant to inactivation by protein C
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- History / PE:
- Recurrent thrombotic complications
Recurrent miscarriages (women) -
- Differential Diagnosis:
- Protein C deficiency
Protein S deficiency
Antithrombin III deficiency
Hyperhomocysteinemia
Antiphospholipid syndrome (acquired)
