Clinical Pathology
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Tumor-Infiltrating Lymphocytes Improve Magee Equation–Based Prediction of Pathologic Complete Response in HR-Positive/HER2-Negative Breast Cancer
Abstract Objectives Magee equation 3 (ME3) is predictive of the pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients…
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Quantification and Significance of Extramedullary Hematopoiesis Seen on Liver Biopsy Specimens
Abstract Objectives Extramedullary hematopoiesis (EMH) may occur in the liver and is often considered pathologic in adults. Many hematologic and…
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Combined Biomarker of Bright CD38 and MYC ≥55% Is Highly Predictive of Double-/Triple-Hit High-Grade B-Cell Lymphoma: Implication on Diagnostic Workup
Abstract Objectives Diagnosis of high-grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements (double-/triple-hit lymphoma [DTHL]) appears to mandate…
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Diagnostic Impact of Next-Generation Sequencing Panels for Lymphoproliferative Neoplasms on Small-Volume Biopsies
Abstract Objectives We investigated the feasibility and utility of next-generation sequencing (NGS)–based targeted somatic mutation panels and IG/TR gene rearrangement…
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Prognostic Significance of Three-Tiered World Health Organization Classification of Phyllodes Tumor and Correlation to Singapore General Hospital Nomogram
Abstract Objectives Phyllodes tumors (PTs) are categorized by the World Health Organization (WHO) as benign, borderline, and malignant. Singapore General…
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Adequacy in Endocervical Curettage
Abstract Objectives Specimen adequacy is an important quality assurance component of a cervical Papanicolaou test. Although consensus exists on minimal…
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Less Is More: Evaluation of Gross Examination Protocol for Cystectomy Specimens Following Neoadjuvant Chemotherapy
Abstract Objectives Neoadjuvant chemotherapy (NAC) confers a survival advantage for muscle-invasive bladder cancer and is now recommended for chemotherapy-eligible patients.…
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Peritubular Capillaritis in Native Kidney Biopsies
Abstract Objectives To determine the frequency and predictors of peritubular capillaritis (PTCitis) among native kidney biopsies. Methods Consecutive native kidney…
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Laboratory Interventions to Eliminate Unnecessary Rapid COVID-19 Testing During a Reagent Shortage
Abstract Objectives In the fall of 2020, US medical centers were running out of rapid coronavirus disease 2019 (COVID-19) tests.…
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High Counts in Hematologic Malignancies Predict Low Metaphase Yield for Cytogenetic Analysis: Nature or Nurture?
Abstract Objectives This study examined the impact of various preanalytical variables on metaphase yield in hematologic malignancies. Methods Marrow samples…
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